Back to Search
Start Over
Functional role of peroxiredoxin 6 in the eye.
- Source :
-
Free radical biology & medicine [Free Radic Biol Med] 2018 Oct; Vol. 126, pp. 210-220. Date of Electronic Publication: 2018 Aug 16. - Publication Year :
- 2018
-
Abstract
- Peroxiredoxin 6 (Prdx6) is the only mammalian 1-Cys member of the Prdx family, a group of enzymes which share the ability to reduce peroxides. In addition to its peroxidase function, Prdx6 also demonstrates phospholipase A <subscript>2</subscript> and lysophosphatidylcholine acyl transferase (LPCAT) activities. These enzymatic activities play an important role in regenerating oxidized membrane phospholipids and maintaining an appropriate balance of intracellular reactive oxygen species. Development of clinical pathologies, including those within the eye, have been linked to dysregulation of Prdx6 function. Interplay between external stressors like exposure to UV light, transforming growth factor β (TGF-β), and hyperglycemia in conjunction with diminished Prdx6 levels and loss of redox balance is associated with cellular changes in a variety of ophthalmic pathologies including cataracts, glaucoma, and retinal degeneration. Many of these cellular abnormalities can be rescued through supplementation with exogenous Prdx6. Additionally, corneal endothelial cells have been found to express high levels of Prdx6 in the plasma membrane. These findings highlight the importance of Prdx6 as an essential regulator of oxidative stress in the eye.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Antioxidants chemistry
Apoptosis genetics
Cataract pathology
Endothelium, Corneal metabolism
Endothelium, Corneal pathology
Humans
Oxidation-Reduction
Peroxiredoxin VI chemistry
Reactive Oxygen Species chemistry
Ultraviolet Rays
Antioxidants metabolism
Cataract genetics
Oxidative Stress genetics
Peroxiredoxin VI genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4596
- Volume :
- 126
- Database :
- MEDLINE
- Journal :
- Free radical biology & medicine
- Publication Type :
- Academic Journal
- Accession number :
- 30120980
- Full Text :
- https://doi.org/10.1016/j.freeradbiomed.2018.08.017