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Vitamin D receptor gene polymorphism influences lipid profile in patients with juvenile idiopathic arthritis.
- Source :
-
Clinical rheumatology [Clin Rheumatol] 2019 Jan; Vol. 38 (1), pp. 117-124. Date of Electronic Publication: 2018 Aug 20. - Publication Year :
- 2019
-
Abstract
- Vitamin D receptor (VDR) gene FokI (rs2228570) polymorphism was postulated to influence outcome of several inflammatory diseases. The aim of this study was to evaluate the influence of rs2228570 polymorphism on lipid profile and on outcome in patients with juvenile idiopathic arthritis (JIA) treated with etanercept. A total of 153 subjects (62 JIA patients and 91 controls) were screened for the rs2228570 using the PCR-RFLP method. Lipid profile (cholesterol, triacylglycerol, HDL-C, and LDL-C) was determined using standard biochemical analysis in controls, while in JIA patients, it was determined prior to and 12 months after anti-TNF (etanercept) therapy. Clinical outcome was assessed using the JIA-American College of Rheumatology (ACR) response criteria. There were significant differences in the distribution of genotypes (p = 0.024) and alleles (p = 0.006; OR = 2.222, 95% CI 1.136-4.348) of the rs2228570 between patients and controls. Etanercept treatment significantly increased HDL-C levels (p = 0.006) in JIA patients with FF genotype in comparison to baseline values. No significant differences were seen in JIA-ACR 30/50/70 responses at month 12 between FF and Ff/ff genotype carriers. This is the first study to demonstrate the protective effect of the VDR FokI FF genotype on lipid profile in JIA patients treated with etanercept. However, this has to be confirmed in a larger cohort of patients.
- Subjects :
- Adolescent
Adult
Alleles
Antirheumatic Agents therapeutic use
Arthritis, Juvenile blood
Case-Control Studies
Child
Child, Preschool
Female
Genotype
Humans
Logistic Models
Male
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Tumor Necrosis Factor-alpha antagonists & inhibitors
Young Adult
Arthritis, Juvenile drug therapy
Arthritis, Juvenile genetics
Etanercept therapeutic use
Lipids blood
Receptors, Calcitriol genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1434-9949
- Volume :
- 38
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 30128913
- Full Text :
- https://doi.org/10.1007/s10067-018-4264-2