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Welding fume exposure is associated with inflammation: a global metabolomics profiling study.
- Source :
-
Environmental health : a global access science source [Environ Health] 2018 Aug 22; Vol. 17 (1), pp. 68. Date of Electronic Publication: 2018 Aug 22. - Publication Year :
- 2018
-
Abstract
- Background: Increasing evidence suggests that welding fume exposure is associated with systemic inflammation. Although celluar metabolites may be associated with inflammation, there is limited information on metabolomic changes during welding fume exposure. Such changes may play an important role in the occurrence, development, and prevention of metal-associated diseases. We aim to investigate human metabolomics changes pre- and post-welding fume exposure.<br />Methods: This study included 52 boilermakers totally. We collected plasma samples pre- and post-shift welding fume exposure and prepared samples using the automated MicroLab STAR® system. Metabolite concentrations were measured using ultra performance liquid chromatography - tandem mass spectrometer (UPLC-MS/MS) methods. Two-way analysis of variance was used to test the significance of metabolite changes with false discovery rate correction.<br />Results: Analysis detected several metabolic changes after welding fume exposure, mainly involved in the lipid pathway [glucocorticoid class (cortisol, corticosterone, and cortisone), acylcarnitine class, and DiHOME species (9,10-DiHOME and 12,13-DiHOME)], amino acid utilization (isoleucine, proline and phenylalanine), and S-(3-hydroxypropyl) mercapturic acid (3-HPMA). These compounds are all associated with inflammation according to previous studies. Further, additive interaction effects linked smoking and 3-HPMA levels. In the metabolite set enrichment analysis for diseases, the top two disease-associated metabolite pathways were systemic inflammation-related diseases including rheumatoid arthritis and systemic lupus erythematosus.<br />Conclusions: This global metabolomics study shows evidence that metabolite changes during welding fume exposure are closely associated with systemic inflammation. The altered metabolites detected may be potential health monitoring biomarkers for boilermakers, especially for inflammation-related disease prevention.
- Subjects :
- Adult
Biomarkers analysis
Cohort Studies
Female
Humans
Inflammation chemically induced
Male
Massachusetts epidemiology
Metabolomics
Middle Aged
Welding
Air Pollutants, Occupational adverse effects
Inflammation epidemiology
Inhalation Exposure adverse effects
Occupational Exposure adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1476-069X
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Environmental health : a global access science source
- Publication Type :
- Academic Journal
- Accession number :
- 30134906
- Full Text :
- https://doi.org/10.1186/s12940-018-0412-z