[Aging-related frailty and sarcopenia. Frailty and Sarcopenia in Patients with Lifestyle-Related Diseases.]

Diabetes can be associated with development or worsening of frailty and sarcopenia via insulin resistance, inflammation or hyperglycemia, and U-shaped association is observed between HbA1c and frailty. In the management of diabetes, resistance training, nutritional support and some of the antidiabetic agents can slow the progression of frailty and sarcopenia. In the management of hypertension, intensive blood pressure lowering can lead to worse outcomes in older adults with severe frailty. The inhibitors of renin-angiotensin system can slow the progression of frailty and sarcopenia.