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'NOTCHing up' the In Vitro Production of Dendritic Cells.
- Source :
-
Trends in immunology [Trends Immunol] 2018 Oct; Vol. 39 (10), pp. 765-767. Date of Electronic Publication: 2018 Aug 24. - Publication Year :
- 2018
-
Abstract
- Two studies show that adding NOTCH ligands to Flt3L cultures increases the yield of cDC1s from mouse and human progenitors. Moreover, these NOTCH-DCs more closely resemble in vivo DCs transcriptionally and functionally. This will be extremely valuable for studying DCs in vitro and for further developing autologous DC-based antitumor vaccinations.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Humans
Mice
Dendritic Cells
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 1471-4981
- Volume :
- 39
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Trends in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 30150090
- Full Text :
- https://doi.org/10.1016/j.it.2018.08.002