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Chlorhexidine-encapsulated mesoporous silica-modified dentin adhesive.
- Source :
-
Journal of dentistry [J Dent] 2018 Nov; Vol. 78, pp. 83-90. Date of Electronic Publication: 2018 Aug 25. - Publication Year :
- 2018
-
Abstract
- Objectives: This work aims to explore the feasibility of chlorhexidine-encapsulated mesoporous silica (CHX@pMSN) as a modifier of a commercial dental adhesive via the evaluation of physicochemical properties and antibacterial capabilities of adhesive-dentin interface.<br />Methods: Therapeutic adhesives were developed in the present study by incorporating CHX@pMSN into a commercial adhesive at four mass fractions (0, 1, 5 and 10 wt.%). The antibacterial capability on Streptococcus mutans (S. mutans) biofilm, conversion degree, adhesive morphology, microtensile bond strength (MTBS) and nanoleakage expression were evaluated comprehensively.<br />Results: MTT and CLSM evaluation showed that CHX@pMSN-doped adhesive inhibits S. mutans biofilm growth, while CHX is released from the modified adhesive continuously. The incorporation of CHX@pMSN did not affect immediate bond strength at the concentration of 1% and 5% (P > 0.05). Moreover, these bonds were mainly preserved in 5% CHX@pMSN group after one month of collagenase ageing. Meanwhile, CHX@pMSN-doped adhesive groups exhibited similar nanoleakage distribution compared with the control.<br />Conclusion: This study showed that the 5% CHX@pMSN-modified adhesive achieved balance amongst unaffected immediate bonding strength, well-preserved bonds against collagenase ageing and effective inhibition of S. mutans biofilm growth.<br />Clinical Significance: CHX@pMSN-modified dentin adhesive can potentially extend the service life of adhesive restoration in clinic.<br /> (Copyright © 2018. Published by Elsevier Ltd.)
- Subjects :
- Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Dental Bonding standards
Materials Testing
Streptococcus mutans drug effects
Chemical Phenomena drug effects
Chlorhexidine chemistry
Chlorhexidine pharmacology
Dental Cements chemistry
Dental Cements pharmacology
Silicon Dioxide chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-176X
- Volume :
- 78
- Database :
- MEDLINE
- Journal :
- Journal of dentistry
- Publication Type :
- Academic Journal
- Accession number :
- 30153498
- Full Text :
- https://doi.org/10.1016/j.jdent.2018.08.012