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Dissociation of T8+ cell-mediated cytolytic and suppressor functions in young adults.
- Source :
-
Journal of clinical & laboratory immunology [J Clin Lab Immunol] 1986 Jun; Vol. 20 (2), pp. 51-5. - Publication Year :
- 1986
-
Abstract
- In the normal young adult population, in vitro levels of polyclonally-induced IgG secretion by mononuclear cells (MNCs) vary widely amongst individuals. Levels of IgG secretion correlate with functional suppressor activity of T8+ cells but not with their proportion within the MNCs either prior to culture, or as found in this study, at the end of the culture period. The current study also demonstrates a lack of correlation between T8+ cell-mediated suppressor (Ts) function and a second predominantly T8+ cell-mediated function, alloantigen-directed cytolytic (Tc) activity. Whether this dissociation between Ts and Tc functions reflects quantitative differences in subsets contained within the T8+ population or qualitative differences in the mechanisms required for induction or generation of Ts and Tc remains to be established.
- Subjects :
- Adult
Cell Line
Cytotoxicity Tests, Immunologic
Cytotoxicity, Immunologic
Herpesvirus 4, Human immunology
Humans
Immunoglobulin G metabolism
Isoantigens immunology
T-Lymphocytes, Cytotoxic classification
T-Lymphocytes, Cytotoxic immunology
T-Lymphocytes, Cytotoxic metabolism
T-Lymphocytes, Helper-Inducer metabolism
T-Lymphocytes, Regulatory immunology
T-Lymphocytes, Regulatory metabolism
Suppressor Factors, Immunologic physiology
T-Lymphocytes, Cytotoxic physiology
T-Lymphocytes, Regulatory physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0141-2760
- Volume :
- 20
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of clinical & laboratory immunology
- Publication Type :
- Academic Journal
- Accession number :
- 3016276