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Radiation dosimetry of [ 131 I]ICF01012 in rabbits: Application to targeted radionuclide therapy for human melanoma treatment.
- Source :
-
Medical physics [Med Phys] 2018 Nov; Vol. 45 (11), pp. 5251-5262. Date of Electronic Publication: 2018 Sep 24. - Publication Year :
- 2018
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Abstract
- Purpose: Dosimetry for melanoma-targeted radionuclide therapy (TRT) with [ <superscript>131</superscript> I]ICF01012, a melanin ligand, has been previously evaluated in mice bearing melanomas. In this study, activity distribution and dosimetry are performed on healthy rabbits (Fauve de Bourgogne) using SPECT-CT imaging and ex vivo measurements.<br />Material and Methods: Ex vivo biodistribution (i.v. injection: 370 kBq/kg, n = 2 per point) is performed on blood, eyes, brain, lung, liver, kidneys, heart, stomach, and spleen. Dosimetry calculations follow the MIRD formalism: S values are calculated from CT images using the GATE Monte Carlo platform and activity distributions are obtained from SPECT-CT imaging (i.v. injection: 37 MBq/kg n = 3 per point). A specific study is presented to assess dose to human retina.<br />Results: Time-integrated activities based on SPECT-CT are in accordance with ex vivo measurements except for spleen. Doses to liver and eyes are the most significant, with respectively, 6.38 ± 0.50 Gy/GBq (evaluated through SPECT-CT imaging) and 45.8 ± 7.9 Gy/GBq (evaluated through ex vivo measurements). Characterization of ocular [ <superscript>131</superscript> I]ICF01012 biodistribution in rabbits and quantification of melanin allowed to assess a dose of 3.07 ± 0.70 Gy/GBq to human retina.<br />Conclusion: This study sustains [ <superscript>131</superscript> I]ICF01012 as a good candidate for melanoma TRT and open perspectives for personalized dosimetry calculation during phase I clinical transfer.<br /> (© 2018 American Association of Physicists in Medicine.)
- Subjects :
- Animals
Female
Humans
Male
Melanoma diagnostic imaging
Melanoma metabolism
Quinoxalines pharmacokinetics
Rabbits
Radiometry
Radiotherapy Dosage
Single Photon Emission Computed Tomography Computed Tomography
Software
Tissue Distribution
Tumor Protein, Translationally-Controlled 1
Iodine Radioisotopes therapeutic use
Melanoma radiotherapy
Quinoxalines therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 2473-4209
- Volume :
- 45
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Medical physics
- Publication Type :
- Academic Journal
- Accession number :
- 30179267
- Full Text :
- https://doi.org/10.1002/mp.13165