Back to Search
Start Over
Blood volume measurement using cardiovascular magnetic resonance and ferumoxytol: preclinical validation.
- Source :
-
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance [J Cardiovasc Magn Reson] 2018 Sep 10; Vol. 20 (1), pp. 62. Date of Electronic Publication: 2018 Sep 10. - Publication Year :
- 2018
-
Abstract
- Background: The hallmark of heart failure is increased blood volume. Quantitative blood volume measures are not conveniently available and are not tested in heart failure management. We assess ferumoxytol, a marketed parenteral iron supplement having a long intravascular half-life, to measure the blood volume with cardiovascular magnetic resonance (CMR).<br />Methods: Swine were administered 0.7 mg/kg ferumoxytol and blood pool T <subscript>1</subscript> was measured repeatedly for an hour to characterize contrast agent extraction and subsequent effect on V <subscript>blood</subscript> estimates. We compared CMR blood volume with a standard carbon monoxide rebreathing method. We then evaluated three abbreviated acquisition protocols for bias and precision.<br />Results: Mean plasma volume estimated by ferumoxytol was 61.9 ± 4.3 ml/kg. After adjustment for hematocrit the resultant mean blood volume was 88.1 ± 9.4 ml/kg, which agreed with carbon monoxide measures (91.1 ± 18.9 ml/kg). Repeated measurements yielded a coefficient of variation of 6.9%, and Bland-Altman repeatability coefficient of 14%. The blood volume estimates with abbreviated protocols yielded small biases (mean differences between 0.01-0.06 L) and strong correlations (r <superscript>2</superscript> between 0.97-0.99) to the reference values indicating clinical feasibility.<br />Conclusions: In this swine model, ferumoxytol CMR accurately measures plasma volume, and with correction for hematocrit, blood volume. Abbreviated protocols can be added to diagnostic CMR examination for heart failure within 8 min.
Details
- Language :
- English
- ISSN :
- 1532-429X
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
- Publication Type :
- Academic Journal
- Accession number :
- 30201013
- Full Text :
- https://doi.org/10.1186/s12968-018-0486-3