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Neutrophil LTA4 hydrolases and leukotriene B4 receptors: effects of leukotriene epoxides and their enzymatic products.
- Source :
-
Prostaglandins, leukotrienes, and medicine [Prostaglandins Leukot Med] 1986 Aug; Vol. 23 (2-3), pp. 167-71. - Publication Year :
- 1986
-
Abstract
- A selection of inhibitors of rat and human neutrophil LTA4 hydrolases have been studied in vitro using partially purified enzymes. 5(S)trans 5,6 oxido-7,9-trans-11-cis-eicosatrienoic acid (LTA3) and 5(S)trans 5,6 oxido, 7,9-trans, 11,14,17-cis-eicosapentaenoic acid (LTA5) have been shown to inhibit neutrophil LTA4 hydrolases in a time-dependent manner. The products of hydrolysis of LTA3, LTA4 and LTA5 by human and rat neutrophil LTA4 hydrolase have been shown to displace [3H] LTB4 binding to human and rat neutrophil membranes. The order of displacement of [3H] LTB4 is LTB4 = LTB3 greater than LTB5 and this correlated well with their biological potencies for enhancement of neutrophil aggregation and chemokinesis.
- Subjects :
- Animals
Arachidonic Acids metabolism
Cell Membrane metabolism
Eicosapentaenoic Acid analogs & derivatives
Eicosapentaenoic Acid metabolism
Eicosapentaenoic Acid pharmacology
Epoxide Hydrolases antagonists & inhibitors
Humans
Hydrolysis
Leukotriene A4
Neutrophils metabolism
Neutrophils ultrastructure
Rats
Receptors, Leukotriene B4
Time Factors
Arachidonic Acids pharmacology
Epoxide Hydrolases physiology
Leukotriene B4 metabolism
Neutrophils enzymology
Receptors, Immunologic physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0262-1746
- Volume :
- 23
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Prostaglandins, leukotrienes, and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 3020583
- Full Text :
- https://doi.org/10.1016/0262-1746(86)90181-2