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Neuroleukin: a lymphokine product of lectin-stimulated T cells.
- Source :
-
Science (New York, N.Y.) [Science] 1986 Oct 31; Vol. 234 (4776), pp. 574-81. - Publication Year :
- 1986
-
Abstract
- Neuroleukin is a lymphokine product of lectin-stimulated T cells that induces immunoglobulin secretion by cultured human peripheral blood mononuclear cells. Neuroleukin acts early in the in vitro response that leads to formation of antibody-secreting cells, but continued production of immunoglobulin by differentiated antibody-secreting cells is neuroleukin-independent. Although the factor is not directly mitogenic, cellular proliferation is a late component of the response to neuroleukin. Neuroleukin does not have B-cell growth factor (BCGF) or B-cell differentiation factor (BCDF) activity in defined assays. Neuroleukin-evoked induction of immunoglobulin secretion is both monocyte- and T-cell-dependent.
- Subjects :
- Animals
B-Lymphocytes drug effects
B-Lymphocytes physiology
Bone Marrow metabolism
Cell Line
Cells, Cultured
Deltaretrovirus genetics
Glucose-6-Phosphate Isomerase
Growth Substances genetics
Growth Substances pharmacology
Humans
Immunity, Cellular drug effects
Immunoglobulins biosynthesis
Lectins pharmacology
Leukemia metabolism
Lymphokines genetics
Lymphokines pharmacology
Lymphoma metabolism
Mice
Pokeweed Mitogens pharmacology
Sequence Homology, Nucleic Acid
T-Lymphocytes drug effects
Growth Substances physiology
Lymphokines physiology
T-Lymphocytes physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 234
- Issue :
- 4776
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 3020690
- Full Text :
- https://doi.org/10.1126/science.3020690