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The role of osteopontin in the pathogenesis of placenta percreta.
- Source :
-
Ginekologia polska [Ginekol Pol] 2018; Vol. 89 (8), pp. 437-41. - Publication Year :
- 2018
-
Abstract
- Objective: This study aims to determine how the expression of osteopontin is altered in the placenta percreta by compar-ing osteopontin expression in normal placentas and placenta percreta tissues.<br />Material and Methods: Placental tissues from hysterectomy materials which were histopathologically diagnosed with placenta percreta (study group, n = 20) and placental tissues obtained from normal term pregnancies (control group, n = 20) were immunohistochemically stained with osteopontin antibody. The groups were compared with respect to the intensity of cytoplasmic staining for osteopontin.<br />Results: The study and control groups were similar with respect to age, gravidity, parity, gestational age at birth, number of previous cesarean deliveries and curettages and (p > 0.05 for all). Immediate postoperative hemoglobin was significantly lower and the need for blood transfusion was significantly higher in the study group (p = 0.001 for both). Placental osteo-pontin expression was significantly altered in the study group (p = 0.020). Negative staining for placental osteopontin was significantly more frequent in the placenta percreta group than the control group (9/20 vs 0/20, 45.0% vs 0%, p = 0.037).<br />Conclusion: As reduced placental osteopontin expression was determined in the placenta percreta cases compared to the normal term placenta tissues, osteopontin can be considered to have a role in morbidly adherent placentation. This study is of value as the first study to investigate the changes in osteopontin expression in placenta percreta cases.
Details
- Language :
- English
- ISSN :
- 0017-0011
- Volume :
- 89
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Ginekologia polska
- Publication Type :
- Academic Journal
- Accession number :
- 30215463
- Full Text :
- https://doi.org/10.5603/GP.a2018.0075