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Platelets mediate protective neuroinflammation and promote neuronal plasticity at the site of neuronal injury.
- Source :
-
Brain, behavior, and immunity [Brain Behav Immun] 2018 Nov; Vol. 74, pp. 7-27. Date of Electronic Publication: 2018 Sep 11. - Publication Year :
- 2018
-
Abstract
- It is generally accepted that inflammation within the CNS contributes to neurodegeneration after traumatic brain injury (TBI), but it is not clear how inflammation is initiated in the absence of infection and whether this neuroinflammation is predominantly beneficial or detrimental. We have previously found that brain-enriched glycosphingolipids within neuronal lipid rafts (NLR) induced platelet degranulation and secretion of neurotransmitters and pro-inflammatory factors. In the present study, we compared TBI-induced inflammation and neurodegeneration in wild-type vs. St3gal5 deficient (ST3 <superscript>-/-</superscript> ) mice that lack major CNS-specific glycosphingolipids. After TBI, microglial activation and CNS macrophage infiltration were substantially reduced in ST3 <superscript>-/-</superscript> animals. However, ST3 <superscript>-/-</superscript> mice had a larger area of CNS damage with marked neuronal/axonal loss. The interaction of platelets with NLR stimulated neurite growth, increased the number of PSD95-positive dendritic spines, and intensified neuronal activity. Adoptive transfer and blocking experiments provide further that platelet-derived serotonin and platelet activating factor plays a key role in the regulation of sterile neuroinflammation, hemorrhage and neuronal plasticity after TBI.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Blood Platelets metabolism
Brain metabolism
Brain Injuries, Traumatic physiopathology
Disease Models, Animal
Encephalitis metabolism
Female
Glycolipids metabolism
Glycolipids physiology
Inflammation metabolism
Macrophages metabolism
Male
Mice
Mice, Inbred C57BL
Microglia metabolism
Neurons physiology
Platelet Activating Factor metabolism
Platelet Activating Factor physiology
Serotonin metabolism
Blood Platelets physiology
Neuroimmunomodulation physiology
Neuronal Plasticity physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2139
- Volume :
- 74
- Database :
- MEDLINE
- Journal :
- Brain, behavior, and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 30217533
- Full Text :
- https://doi.org/10.1016/j.bbi.2018.09.009