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The possible role of insulin-like growth factor-1 in osteosarcoma.
- Source :
-
Current problems in cancer [Curr Probl Cancer] 2019 Jun; Vol. 43 (3), pp. 228-235. Date of Electronic Publication: 2018 Sep 07. - Publication Year :
- 2019
-
Abstract
- Osteosarcoma (OS) is a common malignant tumor of bone, of which clear understanding of molecular pathologic process is not yet possible. Insulin-like growth factor-1 (IGF-1) is a hormone that plays vital role in development and function of many tissues. Unfortunately, IGF-1 and its receptor (IGF-1R)'s over-expression have been implicated in carcinogenesis, and indicated to constitute a risk factor for the development of multiple human cancers, including OS. Increased levels of IGF-1 and IGF-1R have been reported in OS, leading to cancer progression through transformation, proliferation, pro-metastasis, and decreased susceptibility to apoptosis. Over-expression of IGF-1/IGF-1R signaling also contributes to tumor cell survival, metastasis, and resistance to chemotherapeutic drugs. IGF-1 has been included as an OS marker recently, and targeting IGF-1 is an interesting and promising approach in OS therapeutics. However more investigations with clinical trials are necessary to validate the use of drugs against IGF-1 that may provide a basis for new therapeutic approaches to treat this devastating disease. This review article focused on the role of IGF-1/IGF-1R in OS progression and therapeutic aspects of OS targeting IGF-1.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Bone Neoplasms metabolism
Bone Neoplasms pathology
Humans
Osteosarcoma metabolism
Osteosarcoma pathology
Prognosis
Signal Transduction
Antineoplastic Agents therapeutic use
Bone Neoplasms drug therapy
Insulin-Like Growth Factor I antagonists & inhibitors
Molecular Targeted Therapy
Osteosarcoma drug therapy
Receptor, IGF Type 1 antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1535-6345
- Volume :
- 43
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Current problems in cancer
- Publication Type :
- Academic Journal
- Accession number :
- 30217668
- Full Text :
- https://doi.org/10.1016/j.currproblcancer.2018.08.008