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A MALDI-TOF Approach to Ubiquitin Ligase Activity.

Authors :
van Tol BDM
Geurink PP
Ovaa H
Source :
Cell chemical biology [Cell Chem Biol] 2018 Sep 20; Vol. 25 (9), pp. 1053-1055.
Publication Year :
2018

Abstract

In this issue of Cell Chemical Biology,De Cesare et al. (2018) report the development of a high-throughput assay that measures E2/E3 enzyme activity by MALDI-TOF mass spectrometry and apply this to screen for small molecule E3 inhibitors. This assay potentially accelerates the drug discovery for the ubiquitin ligation pathway.<br /> (Copyright © 2018. Published by Elsevier Ltd.)

Details

Language :
English
ISSN :
2451-9448
Volume :
25
Issue :
9
Database :
MEDLINE
Journal :
Cell chemical biology
Publication Type :
Academic Journal
Accession number :
30241600
Full Text :
https://doi.org/10.1016/j.chembiol.2018.09.002