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Mutations of genes including DNMT3A detected by next-generation sequencing in thyroid cancer.

Authors :
Guo LC
Zhu WD
Ma XY
Ni H
Zhong EJ
Shao YW
Yu J
Gu DM
Ji SD
Xu HD
Ji C
Yang JM
Zhang Y
Source :
Cancer biology & therapy [Cancer Biol Ther] 2019; Vol. 20 (3), pp. 240-246. Date of Electronic Publication: 2018 Sep 25.
Publication Year :
2019

Abstract

More than 90% of thyroid cancer belongs to the papillary and follicular thyroid carcinomas based on pathological subtypes. Papillary and follicular thyroid carcinoma are generally associated with a good prognosis. In contrast, other pathological subtypes such as poorly-differentiated and anaplastic thyroid carcinoma (PDTC and ATC) have a poor clinical outcome with a short life expectancy. To identify the genetic variations and biomarkers that may potentially distinguish the aggressive form of thyroid cancer, we performed a retrospective analysis of the formalin-fixed paraffin-embedded tumor samples from 50 patients who mainly displayed aggressive thyroid cancer using next-generation sequencing of 416 solid tumor-related genes. We adopted extensive bioinformatic analysis to vigorously remove germline single-nucleotide polymorphism and systematic sequencing errors, and report here that mutation in DNMT3A gene was significantly enriched in patients with PDTC or ATC.

Details

Language :
English
ISSN :
1555-8576
Volume :
20
Issue :
3
Database :
MEDLINE
Journal :
Cancer biology & therapy
Publication Type :
Academic Journal
Accession number :
30252567
Full Text :
https://doi.org/10.1080/15384047.2018.1523856