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Bovine upper alimentary squamous cell carcinoma associated with bracken fern poisoning: Clinical-pathological aspects and etiopathogenesis of 100 cases.
- Source :
-
PloS one [PLoS One] 2018 Sep 26; Vol. 13 (9), pp. e0204656. Date of Electronic Publication: 2018 Sep 26 (Print Publication: 2018). - Publication Year :
- 2018
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Abstract
- Upper digestive tract (UDT) cancer is rare in cattle, however in Southern Brazil, the UDT squamous cell carcinomas (SCCs) are relatively common and have been associated with bracken fern consumption and the presence of papillomas. Although a theory of pathogenesis considers bovine papillomavirus type 4 (BPV-4) as a cofactor in the development of these SCCs, some aspects of the etiopathogenesis of this disease need to be more investigated. In fact, detection of BPV-4 in UDT papillomas is scarce in other regions of the world and has not been performed in Brazil. Therefore, this study had two aims: 1) to analyze the epidemiological, clinical and pathological aspects of 100 natural cases of SCCs in the UDT of cattle grazing on bracken fern (Pteridium arachnoideum) highly contaminated areas, investigating the associations between these parameters; and 2) to investigate the presence of papillomavirus DNA by polymerase chain reaction (PCR) in the UDT papillomas (n = 47) from 30 cattle that also had UDT SCCs. There were statistically significant associations between clinical signs and tumor localization in the UDT; between histological grade of differentiation and tumor localization; and a trend towards significant association between histological grade of differentiation and presence of metastases. The average age of cattle with oropharyngeal SCCs was 7.39 years, with statistically significant difference comparing to cattle with esophageal SCCs (8.6 years). No statistical association was observed among other clinical-pathological parameters (growth pattern and primary site of the tumor) analyzed. No BPV DNA was detected in papillomas by PCR. Therefore, these results suggest the possibility that papillomas of the UDT are not necessarily associated with BPV infection.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Animals
Bovine papillomavirus 4 genetics
Bovine papillomavirus 4 isolation & purification
Brazil
Carcinoma, Squamous Cell etiology
Carcinoma, Squamous Cell pathology
Cattle
Cattle Diseases pathology
Digestive System Neoplasms etiology
Digestive System Neoplasms pathology
Esophageal Neoplasms etiology
Esophageal Neoplasms pathology
Esophageal Neoplasms veterinary
Esophageal Squamous Cell Carcinoma etiology
Esophageal Squamous Cell Carcinoma pathology
Esophageal Squamous Cell Carcinoma veterinary
Female
Male
Oropharyngeal Neoplasms etiology
Oropharyngeal Neoplasms pathology
Oropharyngeal Neoplasms veterinary
Papillomavirus Infections complications
Papillomavirus Infections veterinary
Plant Poisoning complications
Plant Poisoning pathology
Carcinoma, Squamous Cell veterinary
Cattle Diseases etiology
Digestive System Neoplasms veterinary
Plant Poisoning veterinary
Pteridium poisoning
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 13
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 30256853
- Full Text :
- https://doi.org/10.1371/journal.pone.0204656