Quantitative Measurements of Motor Function in Alzheimer's Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study.

Authors :: Jeppesen Kragh F
Bruun M
Budtz-Jørgensen E
Hjermind LE
Schubert R
Reilmann R
Nielsen JE
Hasselbalch SG
Source :: Dementia and geriatric cognitive disorders [Dement Geriatr Cogn Disord] 2018; Vol. 46 (3-4), pp. 168-179. Date of Electronic Publication: 2018 Sep 26.
Publication Year :: 2018
Abstract: Background: This study examines the efficacy of using quantitative measurements of motor dysfunction, compared to clinical ratings, in Alzheimer's disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB).<br />Methods: In this cross-sectional study, 49 patients with a diagnosis of AD (n = 17), FTD (n = 19), or DLB (n = 13) were included and underwent cognitive testing, clinical motor evaluation, and quantitative motor tests: pronation/supination hand tapping, grasping and lifting, and finger and foot tapping.<br />Results: Our results revealed significantly higher Q-Motor values in pronation/supination and in grip lift force assessment in AD, FTD, and DLB compared to healthy controls (HC). Q-Motor values detected significant differences between AD and HC, while clinical ratings did not.<br />Conclusion: Our results suggest that quantitative measurements provide more objective and sensitive measurements of motor dysfunction in dementia.<br /> (© 2018 S. Karger AG, Basel.)

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