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Potential application of cell reprogramming techniques for cancer research.
- Source :
-
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2019 Jan; Vol. 76 (1), pp. 45-65. Date of Electronic Publication: 2018 Oct 03. - Publication Year :
- 2019
-
Abstract
- The ability to control the transition from an undifferentiated stem cell to a specific cell fate is one of the key techniques that are required for the application of interventional technologies to regenerative medicine and the treatment of tumors and metastases and of neurodegenerative diseases. Reprogramming technologies, which include somatic cell nuclear transfer, induced pluripotent stem cells, and the direct reprogramming of specific cell lineages, have the potential to alter cell plasticity in translational medicine for cancer treatment. The characterization of cancer stem cells (CSCs), the identification of oncogene and tumor suppressor genes for CSCs, and the epigenetic study of CSCs and their microenvironments are important topics. This review summarizes the application of cell reprogramming technologies to cancer modeling and treatment and discusses possible obstacles, such as genetic and epigenetic alterations in cancer cells, as well as the strategies that can be used to overcome these obstacles to cancer research.
- Subjects :
- Animals
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Humans
Neoplasms genetics
Neoplasms metabolism
Neoplastic Stem Cells cytology
Neoplastic Stem Cells metabolism
Tumor Microenvironment
Cellular Reprogramming
Cellular Reprogramming Techniques methods
Neoplasms pathology
Neoplastic Stem Cells pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1420-9071
- Volume :
- 76
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cellular and molecular life sciences : CMLS
- Publication Type :
- Academic Journal
- Accession number :
- 30283976
- Full Text :
- https://doi.org/10.1007/s00018-018-2924-7