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Animal Models for Stem Cell-Based Pulp Regeneration: Foundation for Human Clinical Applications.
- Source :
-
Tissue engineering. Part B, Reviews [Tissue Eng Part B Rev] 2019 Apr; Vol. 25 (2), pp. 100-113. Date of Electronic Publication: 2019 Jan 09. - Publication Year :
- 2019
-
Abstract
- Impact Statement: Animal models are essential for tissue regeneration studies. This review summarizes and discusses the small and large animal models, including mouse, ferret, dog, and miniswine that have been utilized to experiment and to demonstrate stem cell-mediated dental pulp tissue regeneration. We describe the models based on the location where the tissue regeneration is tested-either ectopic, semiorthotopic, or orthotopic. Developing and utilizing optimal animal models for both mechanistic and translational studies of pulp regeneration are of critical importance to advance this field.
Details
- Language :
- English
- ISSN :
- 1937-3376
- Volume :
- 25
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Tissue engineering. Part B, Reviews
- Publication Type :
- Academic Journal
- Accession number :
- 30284967
- Full Text :
- https://doi.org/10.1089/ten.TEB.2018.0194