Maternal levels of growth differentiation factor-15 in patients with preeclampsia.

Authors :: Temel Yuksel I
Mathyk BA
Aslan Cetin B
Turhan U
Okumus ZG
Yetkin Yildirim G
Acar DK
Source :: Hypertension in pregnancy [Hypertens Pregnancy] 2018 Nov; Vol. 37 (4), pp. 192-196. Date of Electronic Publication: 2018 Oct 06.
Publication Year :: 2018
Abstract: Objective: Growth differentiation factor-15 (GDF-15) is a stress-induced cytokine and related to the prognosis of cardiovascular diseases. Our purpose is to measure the maternal levels of GDF-15 in patients with early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE).<br />Methods: This cross-sectional study was conducted including 72 pregnant women, 23 with normal pregnancies and 49 with preeclampsia (26 with EOPE and 23 with LOPE). Maternal serum levels of GDF-15 were measured by using enzyme-linked immunosorbent assay kits.<br />Results: The median serum GDF-15 level was found to be the highest in the EOPE group (EOPE: 441.7 pg/ml). The median serum GDF-15 levels were higher in women with preeclampsia than in the control group (309.7 pg/ml vs. 436.6 pg/ml, p: 0.009).<br />Conclusion: Our findings suggest GDF-15 increased as a response to endothelial injury caused by cytokines triggered by preeclampsia.

Subjects :: Adult
Cross-Sectional Studies
Female
Humans
Pregnancy
Pregnancy Trimester, Third blood
Young Adult
Growth Differentiation Factor 15 blood
Pre-Eclampsia blood

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