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Improvement of Glucose Metabolism Following Long-Term Taurocholic Acid Gavage in a Diabetic Rat Model.
- Source :
-
Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2018 Oct 09; Vol. 24, pp. 7206-7212. Date of Electronic Publication: 2018 Oct 09. - Publication Year :
- 2018
-
Abstract
- BACKGROUND Bile acids (BAs) are signaling molecules that participate in maintaining glucose homeostasis. Acute enteral infusion of BAs potently reduces the glycemic response to glucose, associated with an increase of incretin hormones. However, the effect of long-term supplementation of BAs on glucose metabolism has not been fully investigated. MATERIAL AND METHODS Thirty diabetic rats were assigned to a control group (n=10), a low TCA group (L-TCA group, n=10), and a high TCA group (H-TCA group, n=10). Rats in the control group were fed a regular high-fat diet (HFD), while rats in the L-TCA group and H-TCA group were fed a TCA (taurocholic acid)-mixed HFD with the concentrations of 0.05% and 0.3%, respectively, to control the intake of HFD and TCA. Energy intake, body weight, serum insulin, glucose tolerance, insulin sensitivity, GLP-1, and total serum BAs were measured at week 2 and week 12. RESULTS At week 2 there were no significant differences in body weight, daily energy intake, glucose tolerance, serum insulin, insulin sensitivity, GLP-1, or fasting total serum BAs between the 3 groups. At week 12, fasting blood glucose and intragastric glucose tolerance were better in the H-TCA group, with significantly greater insulin and GLP-1 secretion and better insulin sensitivity; no significant differences in body weight, energy intake, or total fasting serum BAs were observed. CONCLUSIONS Long-term supplementation with small doses of TCA was demonstrated to improve glucose metabolism in a diabetic rat model and may be a potential target for diabetes control.
- Subjects :
- Animals
Bile Acids and Salts metabolism
Body Weight drug effects
Diabetes Mellitus, Experimental metabolism
Diabetes Mellitus, Type 2 blood
Diet, High-Fat
Disease Models, Animal
Glucose metabolism
Glucose Tolerance Test
Insulin blood
Insulin Resistance
Male
Rats
Rats, Sprague-Dawley
Taurocholic Acid administration & dosage
Blood Glucose metabolism
Taurocholic Acid pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1643-3750
- Volume :
- 24
- Database :
- MEDLINE
- Journal :
- Medical science monitor : international medical journal of experimental and clinical research
- Publication Type :
- Academic Journal
- Accession number :
- 30298865
- Full Text :
- https://doi.org/10.12659/MSM.912429