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Pyrazinoates as antiparasitic agents against Trypanosoma cruzi.

Authors :
Vasconcelos CI
Varela MT
Torrecilhas AC
Fernandes JPS
Source :
Archiv der Pharmazie [Arch Pharm (Weinheim)] 2018 Nov; Vol. 351 (11), pp. e1800190. Date of Electronic Publication: 2018 Oct 09.
Publication Year :
2018

Abstract

This work reports a repurposing study of pyrazinoic acid (1) and methyl (2), ethyl (3) and 2-chloroethyl (4) ester derivatives with antimycobacterial activity, in assays against Trypanosoma cruzi. The compounds and benznidazole, the standard antitrypanosoma drug, were evaluated in concentrations ranging from 100 to 6.25 μg/mL. The results showed that compounds 2 and 3 (EC <subscript>50</subscript>  = 182 and 447 μM) significantly reduced the infection rate of the parasite into the mammalian cells at 100 μg/mL (p < 0.05) in a similar way to benznidazole. In addition, all the compounds also significantly reduced the number of intracellular parasites (compound 1 at 50 μg/mL, and compounds 2-4 at 100 μg/mL, p < 0.05) in comparison to the control. Compounds 1 and 2 were more effective than benznidazole at 50 μg/mL (p < 0.001). Moreover, compounds 1-4 did not show significant cytotoxicity against THP-1, J774, and HeLa cells (>1000 μM), indicating that they possess considerable selectivity against the parasites. This report represents the first study of such compounds against T. cruzi, indicating the potential of pyrazinoates as antiparasitic agents.<br /> (© 2018 Deutsche Pharmazeutische Gesellschaft.)

Details

Language :
English
ISSN :
1521-4184
Volume :
351
Issue :
11
Database :
MEDLINE
Journal :
Archiv der Pharmazie
Publication Type :
Academic Journal
Accession number :
30298951
Full Text :
https://doi.org/10.1002/ardp.201800190