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Asperimides A-D, anti-inflammatory aromatic butenolides from a tropical endophytic fungus Aspergillus terreus.
- Source :
-
Fitoterapia [Fitoterapia] 2018 Nov; Vol. 131, pp. 50-54. Date of Electronic Publication: 2018 Oct 09. - Publication Year :
- 2018
-
Abstract
- Four new aromatic butenolides, asperimides A-D (1-4), together with a known analogue, butyrolactone I (5), were isolated from solid cultures of a tropical endophytic fungus Aspergillus terreus. The structures of these compounds were elucidated on the basis of spectroscopic methods and electronic circular dichroism calculations. Compounds 1-4 represent the first examples of butenolides with a maleimide core isolated from Aspergillus sp. Inhibitory effects of the isolated compounds on nitric oxide production were investigated in lipopolysaccaride (LPS)-mediated RAW 264.7 cells. Compounds 3 and 4 exhibited potent anti-inflammatory with IC <subscript>50</subscript> values of 0.78 ± 0.06 and 1.26 ± 0.11 μM, respectively.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- 4-Butyrolactone isolation & purification
4-Butyrolactone pharmacology
Animals
Anti-Inflammatory Agents pharmacology
China
Circular Dichroism
Embryophyta microbiology
Endophytes chemistry
Mice
Molecular Structure
Nitric Oxide metabolism
Plant Leaves microbiology
RAW 264.7 Cells
4-Butyrolactone analogs & derivatives
Anti-Inflammatory Agents isolation & purification
Aspergillus chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 131
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 30308231
- Full Text :
- https://doi.org/10.1016/j.fitote.2018.10.011