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[Effect of SIN-1 on the synthesis of leukotrienes in human polymorphonuclear cells].
- Source :
-
Pathologie-biologie [Pathol Biol (Paris)] 1987 Feb; Vol. 35 (2 Pt 2), pp. 238-40. - Publication Year :
- 1987
-
Abstract
- Leukotriene (LT) synthesis triggered with ionophore A23187 or inflammatory stimuli (PAF, fMLP) in human polymorphonuclear leukocytes (PMNL) was markedly decreased by SIN-1, an active metabolite of molsidomine. This inhibition occurred in the absence or in the presence of exogenous arachidonic acid (AA). These results suggest that SIN-1 inhibited both the release of AA from membrane phospholipids and the 5-lipoxygenase activity in human PMNL. Molsidomine was without any effect on LT formation.
Details
- Language :
- French
- ISSN :
- 0369-8114
- Volume :
- 35
- Issue :
- 2 Pt 2
- Database :
- MEDLINE
- Journal :
- Pathologie-biologie
- Publication Type :
- Academic Journal
- Accession number :
- 3031568