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INfluenza Vaccine Indication During therapy with Immune checkpoint inhibitors: a transversal challenge. The INVIDIa study.
- Source :
-
Immunotherapy [Immunotherapy] 2018 Oct; Vol. 10 (14), pp. 1229-1239. - Publication Year :
- 2018
-
Abstract
- Aim: Considering the unmet need for the counseling of cancer patients treated with immune checkpoint inhibitors (CKI) about influenza vaccination, an explorative study was planned to assess flu vaccine efficacy in this population.<br />Methods: INVIDIa was a retrospective, multicenter study, enrolling consecutive advanced cancer outpatients receiving CKI during the influenza season 2016-2017.<br />Results: Of 300 patients, 79 received flu vaccine. The incidence of influenza syndrome was 24.1% among vaccinated, versus 11.8% of controls; odds ratio: 2.4; 95% CI: 1.23-4.59; p = 0.009. The clinical ineffectiveness of vaccine was more pronounced among elderly: 37.8% among vaccinated patients, versus 6.1% of unvaccinated, odds ratio: 9.28; 95% CI: 2.77-31.14; p < 0.0001.<br />Conclusion: Although influenza vaccine may be clinically ineffective in advanced cancer patients receiving CKI, it seems not to negatively impact the efficacy of anticancer therapy.
- Subjects :
- Costimulatory and Inhibitory T-Cell Receptors immunology
Female
Follow-Up Studies
Humans
Incidence
Influenza, Human drug therapy
Influenza, Human epidemiology
Italy epidemiology
Male
Neoplasms drug therapy
Neoplasms epidemiology
Retrospective Studies
Vaccination
Antibodies, Monoclonal therapeutic use
Immunotherapy methods
Influenza A virus immunology
Influenza Vaccines immunology
Influenza, Human immunology
Neoplasms immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1750-7448
- Volume :
- 10
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Immunotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 30326787
- Full Text :
- https://doi.org/10.2217/imt-2018-0080