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Further studies of the efficacy of military, commercial and novel skin decontaminants against the chemical warfare agents sulphur Mustard, Soman and VX.
- Source :
-
Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2019 Feb; Vol. 54, pp. 263-268. Date of Electronic Publication: 2018 Oct 19. - Publication Year :
- 2019
-
Abstract
- Background/aims: Following an incident involving toxic chemicals, deployment of countermeasures before the arrival of specialised services at the scene may provide a "therapeutic" window in which to mitigate skin absorption.<br />Methods: Five potential candidates (itaconic acid, N,N'-methylenebisacrylamide, 2-trifluoromethylacrylic acid, fuller's earth and Fast-Act®) previously found effective against a simulant (methyl salicylate) were evaluated against a 10 μL droplet of <superscript>14</superscript> C-sulphur mustard (HD), soman (GD) or VX applied to the surface of porcine skin mounted on static skin diffusion cells.<br />Results: All the decontaminants applied to the skin 5 min post exposure achieved a marked reduction in the amount of <superscript>14</superscript> C contaminant remaining within the skin at 24 h. Itaconic acid significantly (p < .05) reduced the amount of <superscript>14</superscript> C-HD, GD and VX remaining in the skin at 24 h. Additionally, 2-trifluoromethylacrylic acid significantly reduced the amount of <superscript>14</superscript> C-HD, whilst fuller's earth significantly reduced the amounts of <superscript>14</superscript> C-HD and VX recovered within the skin at 24 h.<br />Conclusion: All of the products evaluated in this study performed well in reducing the dermal absorption of all the chemical warfare agents tested.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-3177
- Volume :
- 54
- Database :
- MEDLINE
- Journal :
- Toxicology in vitro : an international journal published in association with BIBRA
- Publication Type :
- Academic Journal
- Accession number :
- 30347232
- Full Text :
- https://doi.org/10.1016/j.tiv.2018.10.008