Chronopharmacological Characteristics of the Effect of Hepatoprotectors in Experiment?

Authors :: Bunyatyan ND
Kal'ko EA
Drogovoz SM
Kononenko AV
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2018 Oct; Vol. 165 (6), pp. 754-757. Date of Electronic Publication: 2018 Oct 23.
Publication Year :: 2018
Abstract: We studied circadian rhythms of activity of hepatoprotectors (Antral, Carsil, and glutargin) under conditions of acute paracetamol-induced hepatitis simulated in the morning, afternoon, evening, and at night (09.00, 15.00, 21.00, and 03.00). Antral and Carsil exhibited similar chronoprofiles with the maximum hepatoprotective activity at 09.00 and 21.00, while glutargin exhibited circadian pattern opposite and its activity was maximum at 15.00 and 03.00.

Subjects :: Animals
Female
Glutathione metabolism
Oxidative Stress
Rats
Time Factors
Carbamates pharmacology
Circadian Rhythm drug effects
Glutarates pharmacology
Liver drug effects
Liver metabolism
Organometallic Compounds pharmacology
Silymarin pharmacology

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