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Cav-1 (Caveolin-1) and Arterial Remodeling in Adult Moyamoya Disease.
- Source :
-
Stroke [Stroke] 2018 Nov; Vol. 49 (11), pp. 2597-2604. - Publication Year :
- 2018
-
Abstract
- Background and Purpose- Moyamoya disease (MMD) is a unique cerebrovascular occlusive disease characterized by progressive stenosis and negative remodeling of the distal internal carotid artery (ICA). We hypothesized that cav-1 (caveolin-1)-a protein that controls the regulation of endothelial vesicular trafficking and signal transduction-is associated with negative remodeling in MMD. Methods- We prospectively recruited 77 consecutive patients with MMD diagnosed via conventional angiography. Seventeen patients with intracranial atherosclerotic stroke and no RNF213 mutation served as controls. The outer distal ICA diameters were examined using high-resolution magnetic resonance imaging. We evaluated whether the degree of negative remodeling in the patients with MMD was associated with RNF213 polymorphism, cav-1 levels, or various clinical and vascular risk factors. We also investigated whether the derived factor was associated with negative remodeling at the cellular level using the tube formation and apoptosis assays. Results- The serum cav-1 level was lower in the patients with MMD than in the controls (0.47±0.29 versus 0.86±0.68 ng/mL; P=0.034). The mean ICA diameter was 2.48±0.98 mm for the 126 affected distal ICAs in patients with MMD and 3.84±0.42 mm for the asymptomatic ICAs in the controls ( P<0.001). After adjusting for confounders, cav-1 levels (coefficient, 1.018; P<0.001) were independently associated with the distal ICA diameter in patients with MMD. In vitro analysis showed that cav-1 downregulation suppressed angiogenesis in the endothelial cells and induced apoptosis in the smooth muscle cells. Conclusions- Our findings suggest that cav-1 may play a major role in negative arterial remodeling in MMD.
- Subjects :
- Adult
Apoptosis
Asian People genetics
Carotid Stenosis diagnostic imaging
Carotid Stenosis genetics
Carotid Stenosis metabolism
Case-Control Studies
Cerebral Angiography
Endothelial Cells
Female
Humans
Male
Middle Aged
Moyamoya Disease diagnostic imaging
Moyamoya Disease metabolism
Myocytes, Smooth Muscle
Neovascularization, Physiologic
Pregnancy
Vascular Remodeling physiology
Adenosine Triphosphatases genetics
Carotid Artery, Internal diagnostic imaging
Caveolin 1 metabolism
Moyamoya Disease genetics
Ubiquitin-Protein Ligases genetics
Vascular Remodeling genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4628
- Volume :
- 49
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Stroke
- Publication Type :
- Academic Journal
- Accession number :
- 30355208
- Full Text :
- https://doi.org/10.1161/STROKEAHA.118.021888