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CD49b defines functionally mature Treg cells that survey skin and vascular tissues.
- Source :
-
The Journal of experimental medicine [J Exp Med] 2018 Nov 05; Vol. 215 (11), pp. 2796-2814. Date of Electronic Publication: 2018 Oct 24. - Publication Year :
- 2018
-
Abstract
- Regulatory T (Treg) cells prevent autoimmunity by limiting immune responses and inflammation in the secondary lymphoid organs and nonlymphoid tissues. While unique subsets of Treg cells have been described in some nonlymphoid tissues, their relationship to Treg cells in secondary lymphoid organs and circulation remains unclear. Furthermore, it is possible that Treg cells from similar tissue types share largely similar properties. We have identified a short-lived effector Treg cell subset that expresses the α <subscript>2</subscript> integrin, CD49b, and exhibits a unique tissue distribution, being abundant in peripheral blood, vasculature, skin, and skin-draining lymph nodes, but uncommon in the intestines and in viscera-draining lymph nodes. CD49b <superscript>+</superscript> Treg cells, which display superior functionality revealed by in vitro and in vivo assays, appear to develop after multiple rounds of cell division and TCR-dependent activation. Accordingly, single-cell RNA-seq analysis placed these cells at the apex of the Treg developmental trajectory. These results shed light on the identity and development of a functionally potent subset of mature effector Treg cells that recirculate through and survey peripheral tissues.<br /> (© 2018 Fan et al.)
- Subjects :
- Animals
Integrin alpha2 genetics
Lymph Nodes blood supply
Lymph Nodes cytology
Lymph Nodes immunology
Mice
Mice, Transgenic
Skin blood supply
Skin cytology
T-Lymphocytes, Regulatory cytology
Blood Vessels immunology
Immunologic Surveillance
Integrin alpha2 immunology
Skin immunology
T-Lymphocytes, Regulatory immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1540-9538
- Volume :
- 215
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 30355617
- Full Text :
- https://doi.org/10.1084/jem.20181442