Back to Search
Start Over
Efficacy of rhBMP-2 in Cleft Lip and Palate Defects: Systematic Review and Meta-analysis.
- Source :
-
Calcified tissue international [Calcif Tissue Int] 2019 Feb; Vol. 104 (2), pp. 115-129. Date of Electronic Publication: 2018 Oct 26. - Publication Year :
- 2019
-
Abstract
- The aim of this study was to analyze the efficacy of using rhBMP-2 (recombinant human morphogenetic protein-2) in the treatment of patients with cleft lip and palate defects (CLPD). Seven databases were screened: PubMed (Medline), Lilacs, Ibecs, Web of Science, BBO, Scopus, and The Cochrane Library. Clinical trials that evaluated the use of bioactive treatment with rhBMP-2 in the treatment of patients with CLPD were included. Statistical analyses were performed by comparing the standardized mean difference of bone formation volume and bone filling percentage (p = 0.05). Ten studies compared the use of rhBMP-2 and iliac crest bone graft (ICBG). The global analysis for bone formation volume and bone filling percentage showed that bioactive materials were similar to ICBG with a standardized mean difference of respectively 0.07 (95% CI - 0.41 to 0.56) and 0.24 (95% CI - 0.32 to 0.80). The available literature suggested that use of rhBMP-2 presented similar bone formation results to those of ICBG in secondary alveolar bone grafting for patients with CLPD.
- Subjects :
- Bone Transplantation methods
Cleft Lip epidemiology
Cleft Palate epidemiology
Humans
Maxillofacial Abnormalities drug therapy
Maxillofacial Abnormalities epidemiology
Palate drug effects
Palate embryology
Palate physiology
Recombinant Proteins therapeutic use
Treatment Outcome
Bone Morphogenetic Protein 2 therapeutic use
Cleft Lip drug therapy
Cleft Palate drug therapy
Transforming Growth Factor beta therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0827
- Volume :
- 104
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Calcified tissue international
- Publication Type :
- Academic Journal
- Accession number :
- 30367200
- Full Text :
- https://doi.org/10.1007/s00223-018-0486-1