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Injectable hydrogel encapsulating Cu 2 MnS 2 nanoplates for photothermal therapy against breast cancer.
- Source :
-
Journal of nanobiotechnology [J Nanobiotechnology] 2018 Oct 27; Vol. 16 (1), pp. 83. Date of Electronic Publication: 2018 Oct 27. - Publication Year :
- 2018
-
Abstract
- Background: In order to explore the possibility of treating breast cancer by local photo-therapy, a photothermal agents loaded in situ hydrogel was established. In detail, The Cu <subscript>2</subscript> MnS <subscript>2</subscript> nanoplates were prepared by one-pot synthesis and, the thermosensitive Pluronic F127 was used as the hydrogel matrix. The Cu <subscript>2</subscript> MnS <subscript>2</subscript> nanoplates and the hydrogel were characterized by morphous, particle size, serum stability, photothermal performance upon repeated 808 nm laser irradiation as well as the rheology features. The therapeutic effects of the Cu <subscript>2</subscript> MnS <subscript>2</subscript> nanoplates and the hydrogel were evaluated qualitatively and quantitatively in 4T1 mouse breast cancer cells. The retention, photothermal efficacy, therapeutic effects and systemic toxicity of the hydrogel were assessed in tumor bearing mouse model.<br />Results: The Cu <subscript>2</subscript> MnS <subscript>2</subscript> nanoplates with a diameter of about 35 nm exhibited satisfying serum stability, photo-heat conversion ability and repeated laser exposure stability. The hydrogel encapsulation did not negatively influence the above features of the photothermal agent. The nanoplates loaded in situ hydrogel shows a phase transition at body temperature and, as a result, a long retention in vivo.<br />Conclusions: The photothermal agent embedded hydrogel played a promising photothermal therapeutic effects in tumor bearing mouse model with low systemic toxicity after peritumoral administration.
- Subjects :
- Animals
Cell Line, Tumor
Female
Mammary Neoplasms, Animal pathology
Mice, Inbred BALB C
Nanoparticles ultrastructure
Poloxamer chemistry
Copper chemistry
Hydrogels chemistry
Hyperthermia, Induced
Injections
Mammary Neoplasms, Animal therapy
Manganese chemistry
Nanoparticles chemistry
Phototherapy
Sulfides chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1477-3155
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of nanobiotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 30368238
- Full Text :
- https://doi.org/10.1186/s12951-018-0409-3