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In-situ insertion of multi-walled carbon nanotubes in the Fe 3 O 4 /N/C composite derived from iron-based metal-organic frameworks as a catalyst for effective sensing acetaminophen and metronidazole.
- Source :
-
Talanta [Talanta] 2019 Feb 01; Vol. 193, pp. 100-109. Date of Electronic Publication: 2018 Sep 19. - Publication Year :
- 2019
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Abstract
- In this paper, a novel Fe <subscript>3</subscript> O <subscript>4</subscript> /N/C@MWCNTs composite derived from iron-based metal-organic frameworks (H <subscript>2</subscript> N-Fe-MIL-88B) with multi-walled carbon nanotubes (MWCNTs) was prepared successfully through a simple calcination process. X-ray diffraction, scanning electron microscopy, transmission electron microscopy, Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy and electrochemical measurements were employed to comprehensive characterize the composites. Compare with the physical mixture, in-situ insertion of MWCNTs in the Fe <subscript>3</subscript> O <subscript>4</subscript> /N/C formed Fe <subscript>3</subscript> O <subscript>4</subscript> /N/C@MWCNTs composite has the higher conductivity, larger BET surface area and more satisfying electrocatalytic properties. Meanwhile, this composite with the reasonable combinations exhibits remarkable electrocatalytic activities for acetaminophen (AP) and metronidazole (MNZ) due to the synergistic interaction between the components. Thus, the Fe <subscript>3</subscript> O <subscript>4</subscript> /N/C@MWCNTs-2-600-based electrochemical sensor was established to effectively detect these two medicine molecules, respectively. In the optimized test conditions, the proposed sensor exhibits a wide linear response (0.5-5.0 μM and 5.0-1355.0 μM) for AP and the limit of detection (LOD) was achieved to be 0.14 μM (S/N = 3). Meanwhile, this sensor also shows two linear relationships with the concentration of MNZ in the range of 1.0 μM to 10.0 μM and 10.0 μM to 725.0 μM with the LOD of 0.19 μM (S/N = 3). Moreover, the satisfactory results were also acquired when the proposed sensor was used for the determination of AP and MNZ in the human serum and urine, demonstrating great promising of this electrochemical sensor for clinical applications.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Acetaminophen blood
Acetaminophen urine
Catalysis
Electrochemical Techniques methods
Humans
Limit of Detection
Metronidazole blood
Metronidazole urine
Oxidation-Reduction
Acetaminophen analysis
Magnetite Nanoparticles chemistry
Metal-Organic Frameworks chemistry
Metronidazole analysis
Nanocomposites chemistry
Nanotubes, Carbon chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3573
- Volume :
- 193
- Database :
- MEDLINE
- Journal :
- Talanta
- Publication Type :
- Academic Journal
- Accession number :
- 30368277
- Full Text :
- https://doi.org/10.1016/j.talanta.2018.09.065