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Paper Origami-Inspired Design and Actuation of DNA Nanomachines with Complex Motions.
- Source :
-
Small (Weinheim an der Bergstrasse, Germany) [Small] 2018 Nov; Vol. 14 (47), pp. e1802580. Date of Electronic Publication: 2018 Oct 11. - Publication Year :
- 2018
-
Abstract
- Significant progress in DNA nanotechnology has accelerated the development of molecular machines with functions like macroscale machines. However, the mobility of DNA self-assembled nanorobots is still dramatically limited due to challenges with designing and controlling nanoscale systems with many degrees of freedom. Here, an origami-inspired method to design transformable DNA nanomachines is presented. This approach integrates stiff panels formed by bundles of double-stranded DNA connected with foldable creases formed by single-stranded DNA. To demonstrate the method, a DNA version of the paper origami mechanism called a waterbomb base (WBB) consisting of six panels connected by six joints is constructed. This nanoscale WBB can follow four distinct motion paths to transform between five distinct configurations including a flat square, two triangles, a rectangle, and a fully compacted trapezoidal shape. To achieve this, the sequence specificity of DNA base-pairing is leveraged for the selective actuation of joints and the ion-sensitivity of base-stacking interactions is employed for the flattening of joints. In addition, higher-order assembly of DNA WBBs into reconfigurable arrays is achieved. This work establishes a foundation for origami-inspired design for next generation synthetic molecular robots and reconfigurable nanomaterials enabling more complex and controllable motion.<br /> (© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- DNA chemistry
Nanostructures chemistry
Nanotechnology methods
Subjects
Details
- Language :
- English
- ISSN :
- 1613-6829
- Volume :
- 14
- Issue :
- 47
- Database :
- MEDLINE
- Journal :
- Small (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 30369060
- Full Text :
- https://doi.org/10.1002/smll.201802580