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Silent Cerebral Infarctions with Reduced, Mid-Range and Preserved Ejection Fraction in Patients with Heart Failure.
- Source :
-
Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2018 Sep; Vol. 111 (3), pp. 419-422. - Publication Year :
- 2018
-
Abstract
- Heart failure predisposes to an increased risk of silent cerebral infarction, and data related to left ventricular ejection fraction are still limited. Our objective was to describe the clinical and echocardiographic characteristics and factors associated with silent cerebral infarction in patients with heart failure, according to the left ventricular ejection fraction groups. A prospective cohort was performed at a referral hospital in Cardiology between December 2015 and July 2017. The left ventricular ejection fraction groups were: reduced (≤ 40%), mid-range (41-49%) and preserved (≥ 50%). All patients underwent cranial tomography, transthoracic and transesophageal echocardiography. Seventy-five patients were studied. Silent cerebral infarction was observed in 14.7% of the study population (45.5% lacunar and 54.5% territorial) and was more frequent in patients in the reduced left ventricular ejection fraction group (29%) compared with the mid-range one (15.4%, p = 0.005). There were no cases of silent cerebral infarction in the group of preserved left ventricular ejection fraction. In the univariate analysis, an association was identified between silent cerebral infarction and reduced (OR = 8.59; 95%CI: 1.71 - 43.27; p = 0.009) and preserved (OR = 0.05; 95%CI: 0.003-0.817, p = 0.003) left ventricular ejection fraction and diabetes mellitus (OR = 4.28, 95%CI: 1.14-16.15, p = 0.031). In patients with heart failure and without a clinical diagnosis of stroke, reduced and mid-range left ventricular ejection fractions contributed to the occurrence of territorial and lacunar silent cerebral infarction, respectively. The lower the left ventricular ejection fraction, the higher the prevalence of silent cerebral infarction.
- Subjects :
- Aged
Asymptomatic Diseases
Cerebral Infarction diagnostic imaging
Diabetes Mellitus physiopathology
Echocardiography
Female
Heart Failure diagnostic imaging
Humans
Male
Middle Aged
Prospective Studies
Statistics, Nonparametric
Tomography, X-Ray Computed
Ventricular Function, Left physiology
Cerebral Infarction physiopathology
Heart Failure physiopathology
Stroke Volume physiology
Subjects
Details
- Language :
- English; Portuguese
- ISSN :
- 1678-4170
- Volume :
- 111
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Arquivos brasileiros de cardiologia
- Publication Type :
- Academic Journal
- Accession number :
- 30379259
- Full Text :
- https://doi.org/10.5935/abc.20180140