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Effect of preoperative biliary drainage on cholestasis-associated inflammatory and fibrotic gene signatures in perihilar cholangiocarcinoma.

Effect of preoperative biliary drainage on cholestasis-associated inflammatory and fibrotic gene signatures in perihilar cholangiocarcinoma.

Authors :
Reiniers MJ
de Haan L
Weijer R
Wiggers JK
Jongejan A
Moerland PD
Alles LK
van Kampen AHC
van Gulik TM
Heger M
van Golen RF
Source :
The British journal of surgery [Br J Surg] 2019 Jan; Vol. 106 (1), pp. 55-58. Date of Electronic Publication: 2018 Nov 05.
Publication Year :
2019

Abstract

Preoperative biliary drainage (PBD) is used routinely in the evaluation of patients with potentially resectable perihilar cholangiocarcinoma to relieve cholestasis and improve the liver's resilience to surgery. Little preclinical or translatational data are, however, currently available to guide the use of PBD in this patient group. The effect of PBD on hepatic gene expression profiles was therefore studied by microarray analysis. Drainage affects inflammatory and fibrotic gene signatures.<br /> (© 2018 BJS Society Ltd Published by John Wiley & Sons Ltd.)

Details

Language :
English
ISSN :
1365-2168
Volume :
106
Issue :
1
Database :
MEDLINE
Journal :
The British journal of surgery
Publication Type :
Academic Journal
Accession number :
30395349
Full Text :
https://doi.org/10.1002/bjs.11022