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Effect of preoperative biliary drainage on cholestasis-associated inflammatory and fibrotic gene signatures in perihilar cholangiocarcinoma.
Effect of preoperative biliary drainage on cholestasis-associated inflammatory and fibrotic gene signatures in perihilar cholangiocarcinoma.
- Source :
-
The British journal of surgery [Br J Surg] 2019 Jan; Vol. 106 (1), pp. 55-58. Date of Electronic Publication: 2018 Nov 05. - Publication Year :
- 2019
-
Abstract
- Preoperative biliary drainage (PBD) is used routinely in the evaluation of patients with potentially resectable perihilar cholangiocarcinoma to relieve cholestasis and improve the liver's resilience to surgery. Little preclinical or translatational data are, however, currently available to guide the use of PBD in this patient group. The effect of PBD on hepatic gene expression profiles was therefore studied by microarray analysis. Drainage affects inflammatory and fibrotic gene signatures.<br /> (© 2018 BJS Society Ltd Published by John Wiley & Sons Ltd.)
- Subjects :
- Cholestasis genetics
Down-Regulation genetics
Female
Hepatitis genetics
Humans
Liver Cirrhosis genetics
Male
Microarray Analysis
Middle Aged
Preoperative Care methods
Signal Transduction genetics
Up-Regulation genetics
Bile Duct Neoplasms surgery
Cholestasis complications
Drainage methods
Gene Expression genetics
Klatskin Tumor surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2168
- Volume :
- 106
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The British journal of surgery
- Publication Type :
- Academic Journal
- Accession number :
- 30395349
- Full Text :
- https://doi.org/10.1002/bjs.11022