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Salvia miltiorrhiza protects against diabetic nephropathy through metabolome regulation and wnt/β-catenin and TGF-β signaling inhibition.
- Source :
-
Pharmacological research [Pharmacol Res] 2019 Jan; Vol. 139, pp. 26-40. Date of Electronic Publication: 2018 Nov 03. - Publication Year :
- 2019
-
Abstract
- Diabetic nephropathy (DN) is a complication of diabetes that is caused by uncontrolled high blood sugar. It has been reported that Salvia miltiorrhiza (SM) possesses the ability to prevent kidney damage, although the mechanisms remain unclear. The study was to investigate whether and how SM improved DN injury via regulation of metabolome and the molecular mechanisms. In this study, SD rats were fed a high glucose / high fat diet accompanied by 0.5% glucose water. Three weeks later, the rats were given one intraperitoneal injection of 30 mg/kg STZ each day for three days for DN model. The biochemical indicators and metabolomics of plasma, urine and renal tissue were analyzed. Then the western blotting analysis of renal tissue and glomerular mesangial cells were investigated. The results showed that Salvia miltiorrhiza extracts improved the renal injury and regulation of abnormal glycolipid metabolism. The metabolites in serum, urine and renal tissues have been changed significantly. The involved metabolic pathways mainly include phospholipid, arachidonic acid, and pyrimidine metabolisms. Meanwhile, SM inhibited the relative expression levels of wnt4, β-catenin and TGF-β in renal tissue and high-glucose induced glomerular mesangial cells.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Diabetic Nephropathies metabolism
Diabetic Nephropathies pathology
Kidney drug effects
Kidney metabolism
Kidney pathology
Male
Rats, Sprague-Dawley
Signal Transduction
Transforming Growth Factor beta metabolism
Wnt Proteins metabolism
beta Catenin metabolism
Diabetic Nephropathies drug therapy
Metabolome drug effects
Plant Extracts pharmacology
Plant Extracts therapeutic use
Protective Agents pharmacology
Protective Agents therapeutic use
Salvia miltiorrhiza
Subjects
Details
- Language :
- English
- ISSN :
- 1096-1186
- Volume :
- 139
- Database :
- MEDLINE
- Journal :
- Pharmacological research
- Publication Type :
- Academic Journal
- Accession number :
- 30395946
- Full Text :
- https://doi.org/10.1016/j.phrs.2018.10.030