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Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia.
- Source :
-
Nature genetics [Nat Genet] 2018 Dec; Vol. 50 (12), pp. 1696-1704. Date of Electronic Publication: 2018 Nov 05. - Publication Year :
- 2018
-
Abstract
- The genetic variation in Northern Asian populations is currently undersampled. To address this, we generated a new genetic variation reference panel by whole-genome sequencing of 175 ethnic Mongolians, representing six tribes. The cataloged variation in the panel shows strong population stratification among these tribes, which correlates with the diverse demographic histories in the region. Incorporating our results with the 1000 Genomes Project panel identifies derived alleles shared between Finns and Mongolians/Siberians, suggesting that substantial gene flow between northern Eurasian populations has occurred in the past. Furthermore, we highlight that North, East, and Southeast Asian populations are more aligned with each other than these groups are with South Asian and Oceanian populations.
- Subjects :
- Americas epidemiology
Asia, Northern epidemiology
Asian People statistics & numerical data
Europe epidemiology
Asia, Eastern epidemiology
Female
Gene Flow
Genome, Human
Humans
Male
Mongolia ethnology
Phylogeny
Whole Genome Sequencing
Asian People ethnology
Asian People genetics
Genetics, Population
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 50
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 30397334
- Full Text :
- https://doi.org/10.1038/s41588-018-0250-5