Bisphenol A exposure and type 2 diabetes mellitus risk: a meta-analysis.

Authors :: Hwang S
Lim JE
Choi Y
Jee SH
Source :: BMC endocrine disorders [BMC Endocr Disord] 2018 Nov 06; Vol. 18 (1), pp. 81. Date of Electronic Publication: 2018 Nov 06.
Publication Year :: 2018
Abstract: Background: This meta-analytic study explored the relationship between the risk of type 2 diabetes mellitus (T2DM) and bisphenol A concentrations.<br />Methods: The Embase and Medline (PubMed) databases were searched, using relevant keywords, for studies published between 1980 and 2018. A total of 16 studies, twelve cross-sectional, two case-control and one prospective, were included in the meta-analysis. The odds ratio (OR) and its 95% confidence interval (CI) were determined across the sixteen studies. The OR and its 95% CI of diabetes associated with bisphenol A were estimated using both fixed-effects and random-effects models.<br />Results: A total of 41,320 subjects were included. Fourteen of the sixteen studies included in the analysis provided measurements of urine bisphenol A levels and two study provided serum bisphenol A levels. Bisphenol A concentrations in human bio-specimens showed positive associations with T2DM risk (OR 1.28, 95% CI 1.14, 1.44). A sensitivity analysis indicated that urine bisphenol A concentrations were positively associated with T2DM risk (OR 1.20, 95% CI 1.09, 1.31).<br />Conclusions: This meta-analysis indicated that Bisphenol A exposure is positively associated with T2DM risk in humans.