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Initial presentation determines clinical entity in patients with anti-centromere antibody positivity.
- Source :
-
International journal of rheumatic diseases [Int J Rheum Dis] 2019 Jan; Vol. 22 (1), pp. 103-107. Date of Electronic Publication: 2018 Nov 14. - Publication Year :
- 2019
-
Abstract
- Aim: Anti-centromere antibody (ACA) is often detected in patients with autoimmune diseases, including limited cutaneous systemic sclerosis (SSc), Sjögren's syndrome (SS), and primary biliary cholangitis (PBC). The association between autoimmune disease and ACA positivity remains unclear. We sought to clarify the clinical features of ACA-positive patients and their association with autoantibodies.<br />Method: A total of 309 cases of a discrete-speckled pattern anti-nuclear antibody (ANA) test and/or positive ACA who visited our department were retrospectively enrolled. Clinical and immunological data were collected and statistically analyzed.<br />Result: A proportion of second and/or third ANA patterns were speckled (16%), homogenous (7%), cytoplasmic (3%) and/or nucleolar (3%). Of the 309 patients, 186 had Raynaud's phenomenon, 149 had sclerodactyly, and 162 had oral and/or ocular dryness. A total of 214 patients were classified into 17 autoimmune diseases based on their symptoms at the initial visit, while the other 95 patients did not meet any criteria. Most of the 214 patients were diagnosed with SSc and/or SS; 25 and 22 additional patients were diagnosed with rheumatoid arthritis and PBC, respectively. Higher titers of immunoglobulins were observed in patients diagnosed with autoimmune disease compared to patients without a diagnosis. The mean observation period was 80 months. Three additional patients received interim diagnoses based on new symptoms or organ involvement. In the other patients, the diagnosis made at the first visit was not changed over the observation period.<br />Conclusion: Our study confirmed that many ACA-positive cases can be classified into an autoimmune disease type on presentation.<br /> (© 2018 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Antibodies, Antinuclear blood
Autoimmune Diseases blood
Autoimmune Diseases diagnosis
Biomarkers blood
Female
Fluorescent Antibody Technique
Humans
Male
Middle Aged
Predictive Value of Tests
Prognosis
Retrospective Studies
Serologic Tests
Young Adult
Antibodies, Antinuclear immunology
Autoimmune Diseases immunology
Autoimmunity
Centromere immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1756-185X
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of rheumatic diseases
- Publication Type :
- Academic Journal
- Accession number :
- 30428504
- Full Text :
- https://doi.org/10.1111/1756-185X.13439