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Substance Use and Adherence to HIV Preexposure Prophylaxis for Men Who Have Sex with Men 1 .
- Source :
-
Emerging infectious diseases [Emerg Infect Dis] 2018 Dec; Vol. 24 (12). - Publication Year :
- 2018
-
Abstract
- The effectiveness of oral HIV preexposure prophylaxis (PrEP) strongly depends on maintaining adherence. We investigated the association between substance use and PrEP adherence, as well as incident sexually transmitted infections (STIs) in a high-risk cohort of 394 participants (391 men who have sex with men and 3 transgender women) who were enrolled in a PrEP demonstration project. We assessed baseline and ongoing substance use over a 48-week period for stimulants and nonstimulant substances and for each substance separately. We measured PrEP adherence by using dried blood spots to obtain levels of tenofovir diphosphate. No differences in these levels were found between substance users and nonsubstance users. Baseline stimulant use was strongly associated (odds ratio 3.4; p<0.001) with incident STIs during the study. Thus, PrEP adherence was not decreased by substance use. Because substance users had increased rates of STIs, indicating higher-risk behavior, they might be excellent candidates for PrEP.
- Subjects :
- Alcohol Drinking
California epidemiology
Female
Humans
Male
Proportional Hazards Models
Public Health Surveillance
Randomized Controlled Trials as Topic
Sexual and Gender Minorities
Sexually Transmitted Diseases epidemiology
Sexually Transmitted Diseases prevention & control
HIV Infections epidemiology
HIV Infections prevention & control
Homosexuality, Male
Pre-Exposure Prophylaxis
Substance-Related Disorders epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1080-6059
- Volume :
- 24
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Emerging infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 30457536
- Full Text :
- https://doi.org/10.3201/eid2412.180400