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CD300 receptor family in viral infections.
- Source :
-
European journal of immunology [Eur J Immunol] 2019 Mar; Vol. 49 (3), pp. 364-374. Date of Electronic Publication: 2018 Dec 14. - Publication Year :
- 2019
-
Abstract
- The CD300 molecules constitute an evolutionarily significant family of receptors that are expressed on myeloid and lymphoid cells, but also on other cell types, such as tuft cells. Many of the CD300 receptors have been shown to recognize lipids, e.g. phosphatidylserine and phosphatidylethanolamine. Over the past couple of years, accumulating evidence has shown that this family of receptors is involved in the pathogenesis of many diseases. Specifically, CD300 molecules participate in the mechanisms that viruses employ to develop immune evasion strategies and to infect host cells. The participation of CD300 molecules in viral infection includes both lipid dependent and independent mechanisms, as for example in infections with dengue virus (DENV) and murine norovirus (MNV), respectively. CD300 receptors are also involved in viral escape mechanisms, for instance inhibiting NK cell-mediated cytotoxicity against infected cells. Moreover, it is becoming increasingly recognized that the expression of CD300 receptors is altered during viral diseases. Here, we review the involvement of human and murine CD300 molecules in viral binding and entry and in cellular responses to viruses, which highlights the potential of CD300 molecules in the search of new biomarkers for various stages of infection and therapeutic targets for the treatment of viral infections.<br /> (© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Animals
Antigens, CD metabolism
Dengue Virus physiology
Humans
Lymphocytes immunology
Lymphocytes metabolism
Lymphocytes virology
Mice
Norovirus physiology
Phospholipids metabolism
Receptors, Immunologic metabolism
Virus Diseases metabolism
Virus Diseases virology
Antigens, CD immunology
Dengue Virus immunology
Immune Evasion immunology
Norovirus immunology
Phospholipids immunology
Receptors, Immunologic immunology
Virus Diseases immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4141
- Volume :
- 49
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 30485414
- Full Text :
- https://doi.org/10.1002/eji.201847951