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Sensing acidosis: nociception or sngception?

Authors :
Lin JH
Hung CH
Han DS
Chen ST
Lee CH
Sun WZ
Chen CC
Source :
Journal of biomedical science [J Biomed Sci] 2018 Nov 29; Vol. 25 (1), pp. 85. Date of Electronic Publication: 2018 Nov 29.
Publication Year :
2018

Abstract

Background: Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli.<br />Main Body: In the pain clinic, acid or soreness sensation is a characteristic sensory phenotype of various acute and chronic pain syndromes, such as delayed onset muscle soreness, fibromyalgia, and radicular pain. However, soreness sensation is a sign of successful analgesia for acupuncture and noxipoint therapy. Thus, the nature of acid or soreness sensation is not always nociceptive (or painful) and could be anti-nociceptive. To facilitate the investigation of the molecular and neurobiological mechanisms of soreness sensation, we propose a concept called "sngception (sng- ception)" to describe the response of the somatosensory nervous system to sense tissue acidosis and to distinguish it from nociception. "Sng" is a Taiwanese word that represents the state of soreness while at the same time imitates the natural vocalization of humans feeling sore.<br />Conclusion: Here we propose sngception as a specific somatosensory function that transmits the acid sensation from the peripheral to the central nervous system. Sngception could partially overlap with nociception, but it could also transmit antinociception, proprioception, and pruriception.

Details

Language :
English
ISSN :
1423-0127
Volume :
25
Issue :
1
Database :
MEDLINE
Journal :
Journal of biomedical science
Publication Type :
Academic Journal
Accession number :
30486810
Full Text :
https://doi.org/10.1186/s12929-018-0486-5