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Long-term effects of radioiodine treatment on salivary gland function in adult survivors of pediatric differentiated thyroid carcinoma.
- Source :
-
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2018 Nov 30. Date of Electronic Publication: 2018 Nov 30. - Publication Year :
- 2018
- Publisher :
- Ahead of Print
-
Abstract
- Pediatric differentiated thyroid cancer (DTC) is a rare disease. Initial treatment of DTC consists of a (near) total thyroidectomy and radioactive iodine ( <superscript>131</superscript> I) therapy. Previous studies in adults showed that <superscript>131</superscript> I treatment may result in a reduced salivary gland function. Studies regarding salivary gland function in children treated for DTC are sparse. Our aim was to assess long-term effects of <superscript>131</superscript> I treatment on salivary gland function in survivors of pediatric DTC. Methods: In a nationwide cross-sectional study, salivary gland function of patients treated for pediatric DTC between 1970 and 2013 (>5 years after diagnosis, ≥18 years old at time of evaluation) was studied. Salivary gland function was assessed by sialometry, sialochemistry and a xerostomia inventory. Salivary gland dysfunction was defined as unstimulated whole saliva flow ≤0.2mL/min and/or a stimulated whole saliva flow ≤0.7 mL/min. Results: Sixty-five patients (median age at evaluation 33 [IQR, 25-40] years, 86.2% female, median follow-up period 11 [IQR, 6-22] years) underwent <superscript>131</superscript> I treatment. Median cumulative <superscript>131</superscript> I activity was 5.88 [IQR, 2.92-12.95] GBq, 47.7% underwent multiple <superscript>131</superscript> I administrations. Salivary gland dysfunction was present in 30 (47.6%) patients. Levels of amylase and total protein in saliva were reduced. Moderate to severe xerostomia was present in 22 (35.5%) patients. Stimulated salivary secretion was lower and severity of xerostomia complaints higher in patients treated with higher cumulative <superscript>131</superscript> I activity. Conclusion: In survivors of pediatric DTC, clinically significant salivary gland dysfunction was found in 35.5% and was related to the cumulative <superscript>131</superscript> I activity of the treatment.<br /> (Copyright © 2018 by the Society of Nuclear Medicine and Molecular Imaging, Inc.)
Details
- Language :
- English
- ISSN :
- 1535-5667
- Database :
- MEDLINE
- Journal :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 30504138
- Full Text :
- https://doi.org/10.2967/jnumed.118.212449