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Clinical and Laboratory Characteristics of an Acute Chikungunya Outbreak in Bangladesh in 2017.
- Source :
-
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2019 Feb; Vol. 100 (2), pp. 405-410. - Publication Year :
- 2019
-
Abstract
- From April to September 2017, Bangladesh experienced a huge outbreak of acute Chikungunya virus infection in Dhaka. This series describes the clinical and laboratory features of a large number of cases (690; 399 confirmed and 291 probable) suffered during that period. This observational study was carried out at Dhaka Medical College Hospital, Bangladesh. The median age of the patients at presentation was 38 years (IQR 30-50) with a male (57.3%) predominance. Hypertension and diabetes were the most common comorbidities. The mean (±SD) duration of fever was 3.7 (±1.4) days. Other common manifestations were arthralgia (99.2%), maculopapular rash (50.2%), morning stiffness (49.7%), joint swelling (48.5%), and headache (37.6%). Cases were confirmed by anti-chikungunya IgG (173; 43.3%), IgM (165; 42.3%), and reverse transcription polymerase chain reaction (44; 11.0%). Important laboratory findings include high erythrocyte sedimentation rate (156; 22.6%), raised serum glutamic pyruvic transaminase (73; 10.5%), random blood sugar (54; 7.8%), leukopenia (72; 10.4%), thrombocytopenia (41; 5.9%), and others. The oligo-articular (453; 66.1%) variety of joint involvement was significantly more common compared with the poly-articular (237; 34.5%) variety. Commonly involved joints were the wrist (371; 54.1%), small joints of the hand (321; 46.8%), ankle (251; 36.6%), knee (240; 35.0%), and elbow (228; 33.2%). Eleven cases were found to be complicated with neurological involvement and two of them died. Another patient died due to myocarditis. Public health experts, clinicians, and policymakers could use the results of this study to construct the future strategy tackling chikungunya in Bangladesh and other epidemic countries.
- Subjects :
- Acute Disease
Adult
Arthralgia epidemiology
Arthralgia mortality
Arthralgia physiopathology
Arthralgia virology
Bangladesh epidemiology
Chikungunya Fever mortality
Chikungunya Fever virology
Chikungunya virus genetics
Chikungunya virus isolation & purification
Comorbidity
Diabetes Mellitus epidemiology
Diabetes Mellitus mortality
Diabetes Mellitus physiopathology
Diabetes Mellitus virology
Drug Eruptions epidemiology
Drug Eruptions mortality
Drug Eruptions physiopathology
Drug Eruptions virology
Female
Headache epidemiology
Headache mortality
Headache physiopathology
Headache virology
Humans
Hypertension epidemiology
Hypertension mortality
Hypertension physiopathology
Hypertension virology
Immunoglobulin G blood
Immunoglobulin M blood
Leukopenia epidemiology
Leukopenia mortality
Leukopenia physiopathology
Leukopenia virology
Male
Middle Aged
Survival Analysis
Thrombocytopenia epidemiology
Thrombocytopenia mortality
Thrombocytopenia physiopathology
Thrombocytopenia virology
Antibodies, Viral blood
Chikungunya Fever epidemiology
Chikungunya Fever physiopathology
Chikungunya virus immunology
Disease Outbreaks
Subjects
Details
- Language :
- English
- ISSN :
- 1476-1645
- Volume :
- 100
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The American journal of tropical medicine and hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 30526743
- Full Text :
- https://doi.org/10.4269/ajtmh.18-0636