Back to Search
Start Over
Immunoreactivity for Sox10 in Basaloid Neoplasms of The Skin.
- Source :
-
Applied immunohistochemistry & molecular morphology : AIMM [Appl Immunohistochem Mol Morphol] 2019 Feb; Vol. 27 (2), pp. 114-118. - Publication Year :
- 2019
-
Abstract
- Basaloid tumors of the skin pose a diagnostic challenge to pathologists, because the differential diagnosis is broad, sometimes with subtle differentiating features. We evaluated SOX10 expression in 120 primary cutaneous tumors with epidermal, sweat glandular, neuroendocrine/neuroectodermal, follicular, and sebaceous lineages. Our findings were compared with those of previous studies that evaluated SOX10 in tumors of the skin. SOX10 staining was seen in the majority of sweat gland tumors with the exception of syringoma and microcystic adnexal carcinoma. There were no immunoreactive cases among epidermal, neuroendocrine/neuroectodermal, follicular, or sebaceous tumors. These findings are comparable to reported in previous studies, and show SOX10 can be a useful adjunct in the differential diagnosis of nodular basaloid skin tumors. That marker has less utility in the assessment of sclerosing basaloid cutaneous neoplasms, because such tumors are almost uniformly nonreactive for it.
- Subjects :
- Carcinoma, Basal Cell diagnosis
Carcinoma, Basal Cell pathology
Diagnosis, Differential
Humans
Immunohistochemistry
SOXE Transcription Factors immunology
Skin pathology
Skin Neoplasms diagnosis
Skin Neoplasms pathology
Sweat Gland Neoplasms diagnosis
Sweat Gland Neoplasms pathology
Biomarkers, Tumor metabolism
Carcinoma, Basal Cell metabolism
SOXE Transcription Factors metabolism
Skin metabolism
Skin Neoplasms metabolism
Sweat Gland Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1533-4058
- Volume :
- 27
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Applied immunohistochemistry & molecular morphology : AIMM
- Publication Type :
- Academic Journal
- Accession number :
- 30531326
- Full Text :
- https://doi.org/10.1097/PAI.0000000000000721