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Management of uterine sarcomas and prognostic indicators: real world data from a single-institution.
- Source :
-
BMC cancer [BMC Cancer] 2018 Dec 13; Vol. 18 (1), pp. 1247. Date of Electronic Publication: 2018 Dec 13. - Publication Year :
- 2018
-
Abstract
- Background: Uterine sarcomas consist a heterogeneous group of mesenchymal gynecological malignancies with unclear therapeutic recommendations and unspecific but poor prognosis, since they usually metastasize and tend to recur very often, even in early stages.<br />Methods: We retrospectively analyzed all female patients with uterine sarcomas treated in our institution over the last 17 years. Clinico-pathological data, treatments and outcomes were recorded. Kaplan-Meier curves were plotted and time-to-event analyses were estimated using Cox regression.<br />Results: Data were retrieved from 61 women with a median age of 53 (range: 27-78) years, at diagnosis. Fifty-one patients were diagnosed with leiomyosarcoma (LMS), 3 with high grade endometrial stromal sarcoma (ESS), 5 with undifferentiated uterine sarcoma (UUS), 1 with Ewing sarcoma (ES) and 1 with Rhabdomyosarcoma (RS). 24 cases had stage I, 7 stage II, 14 stage III and 16 stage IV disease. Median disease-free survival (DFS) in adjuvant approach was 18.83 months, and median overall survival (OS) 31.07 months. High mitotic count (> 15 mitoses) was significantly associated with worse OS (P < 0.001) and worse DFS (P = 0.028).<br />Conclusions: Mitotic count appears to be independent prognostic factor while further insights are needed to improve adjuvant and palliative treatment of uterine sarcomas.
- Subjects :
- Adult
Aged
Female
Greece epidemiology
Humans
Middle Aged
Mitotic Index methods
Mitotic Index trends
Prognosis
Retrospective Studies
Rhabdomyosarcoma epidemiology
Rhabdomyosarcoma therapy
Sarcoma, Endometrial Stromal epidemiology
Sarcoma, Endometrial Stromal therapy
Sarcoma, Ewing epidemiology
Sarcoma, Ewing therapy
Disease Management
Rhabdomyosarcoma diagnosis
Sarcoma, Endometrial Stromal diagnosis
Sarcoma, Ewing diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 18
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 30541504
- Full Text :
- https://doi.org/10.1186/s12885-018-5156-1