Back to Search
Start Over
Intrathecal papaverine for the prevention of paraplegia after operation on the thoracic or thoracoabdominal aorta.
- Source :
-
The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 1988 Nov; Vol. 96 (5), pp. 823-9. - Publication Year :
- 1988
-
Abstract
- Eleven patients undergoing operation on the descending or thoracoabdominal aorta were administered papaverine intrathecally in an attempt to protect the spinal cord from ischemic damage. Concurrently, 19 patients, also undergoing operation on the thoracic or thoracoabdominal aorta, were operated on with a variety of conventional techniques, including distal aortic perfusion, but were not given intrathecal papaverine. No signs of early neurologic injury developed in any of the patients in the intrathecal papaverine group, although delayed paraparesis developed in one of the patients (9%; 70% confidence limits = 1% to 28%). On the other hand, eight of 19 patients undergoing operation with conventional techniques had either lower extremity paraparesis or paraplegia postoperatively (42%; 70% confidence limits = 29% to 57%; p = 0.058). Intrathecal papaverine appeared to provide spinal cord protection during thoracic aortic operations, particularly during prolonged periods of aortic cross-clamping. Papaverine was not associated with increased risk and may be superior to other conventionally used modalities. We conclude that continued evaluation of this technique is justified.
- Subjects :
- Adult
Aorta, Abdominal surgery
Aorta, Thoracic surgery
Clinical Trials as Topic
Constriction
Humans
Injections, Spinal
Middle Aged
Papaverine administration & dosage
Regional Blood Flow
Time Factors
Aortic Diseases surgery
Papaverine therapeutic use
Paraplegia prevention & control
Postoperative Complications prevention & control
Spinal Cord blood supply
Subjects
Details
- Language :
- English
- ISSN :
- 0022-5223
- Volume :
- 96
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of thoracic and cardiovascular surgery
- Publication Type :
- Academic Journal
- Accession number :
- 3054343