Mycobacterium avium complex infection in patients with human immunodeficiency virus: A systematic review and meta-analysis.

Authors :: Heidary M
Nasiri MJ
Mirsaeidi M
Jazi FM
Khoshnood S
Drancourt M
Darban-Sarokhalil D
Source :: Journal of cellular physiology [J Cell Physiol] 2019 Jul; Vol. 234 (7), pp. 9994-10001. Date of Electronic Publication: 2018 Dec 12.
Publication Year :: 2019
Abstract: Background: Mycobacterium avium-intracellulare complex (MAC) is one of the leading causes of death among people living with human immunodeficiency virus (HIV). The current study was aimed to determine the frequency of MAC infection in patients infected with HIV.<br />Methods: Embase, PubMed, and Web of Science were searched for relevant studies. All statistical analyses were performed by STATA version 14.<br />Results: From 6,627 retrieved articles, 23 were included in the final analysis. A total of 18,463 patients with HIV were included in the analysis. The frequency of MAC infection in patients with HIV was found to be 10.6% (95% confidence interval, 6.9-14.2).<br />Conclusion: The relatively large fractions of HIV-infected patients were coinfected with MAC, which may poses significant public health problems. Continued progress in the development of rapid diagnostic methods and preventive therapy for MAC should lead to further improvements in survival and quality of life in patients with HIV.<br /> (© 2018 Wiley Periodicals, Inc.)

Subjects :: Adult
Anti-Bacterial Agents therapeutic use
Anti-HIV Agents therapeutic use
Female
HIV Infections diagnosis
HIV Infections drug therapy
HIV Infections mortality
Humans
Male
Mycobacterium avium-intracellulare Infection diagnosis
Mycobacterium avium-intracellulare Infection mortality
Mycobacterium avium-intracellulare Infection prevention & control
Risk Factors
Treatment Outcome
Coinfection
HIV Infections virology
Mycobacterium avium Complex pathogenicity
Mycobacterium avium-intracellulare Infection microbiology

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