Recent, non-classical, approaches to antibody lysine modification.

Authors :: Chaubet G
Thoreau F
Wagner A
Source :: Drug discovery today. Technologies [Drug Discov Today Technol] 2018 Dec; Vol. 30, pp. 21-26. Date of Electronic Publication: 2018 Sep 27.
Publication Year :: 2018
Abstract: This review will discuss recent development in the bioconjugation of lysine residues on antibodies. As several chemoselective reagents have already been developed for modifying amine groups, recent strategies now tend to aim at being site-specific. Four general methods have been listed: kinetically controlled, template-directed or enzymatic strategies as well as the use of chemically programmed antibodies.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)